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Ticoflex 500mg (Naproxen) is indicated for the treatment of:
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Juvenile arthritis
- Tendonitis and bursitis
- Acute gout
- Primary dysmenorrhea (painful menstruation)
- General pain relief
Naproxen works by inhibiting cyclooxygenase (COX), reducing the production of prostaglandins, which leads to reduced inflammation, pain, and fever. It has a high bioavailability of 95%.
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✅ Description:
- Naproxen is an NSAID with anti-inflammatory, analgesic, and antipyretic properties. It works by inhibiting the production of hormone-like substances called prostaglandins that promote inflammation, pain, and fever.
- Naproxen is absorbed from the gastrointestinal tract and achieves 95% bioavailability.
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✔️ Dosage & Administration: Ticoflex 500
For Rheumatoid Arthritis, Osteoarthritis, and Ankylosing Spondylitis:
- Usual dose: 500-1000 mg daily, divided into two doses after meals.
For Pain, Primary Dysmenorrhea, Acute Tendonitis & Bursitis:
- Starting dose: 500 mg, followed by 500 mg every 12 hours or 250 mg every 6-8 hours.
- The initial total daily dose should not exceed 1250 mg, then reduced to 1000 mg/day.
For Acute Gout:
- Starting dose: 750 mg, followed by 250 mg every 8 hours until the attack subsides.
For Juvenile Rheumatoid Arthritis (Children over 2 years):
- Usual dose: 10 mg/kg/day, divided into two doses every 12 hours.
Dosage adjustments may be required for specific conditions and age groups.
- Use caution when interacting with other medications like blood thinners, diuretics, and other NSAIDs.
- Avoid alcohol while using Naproxen to reduce the risk of stomach-related side effects.
✔️ Side Effects: Ticoflex 500
- Gastrointestinal: Heartburn, abdominal pain, nausea, diarrhea, dyspepsia.
- Central Nervous System: Headache, vertigo, drowsiness.
- Dermatological: Itching (pruritus), purpura (bruising).
- Cardiovascular: Edema, palpitation.
- Other: Visual disturbances, hearing disturbances.
✔️ Interactions:
- ACE inhibitors: May reduce the antihypertensive effect.
- Antacids & Sucralfate: Delay absorption of Naproxen.
- Aspirin: May increase adverse effects.
- Diuretics: Reduce the natriuretic effect of furosemide and thiazides.
- Methotrexate: Increases the toxicity of methotrexate.
- Warfarin: May increase the risk of gastrointestinal bleeding.
- Selective Serotonin Reuptake Inhibitors (SSRI): Increases the risk of GI bleeding.
✔️ Contraindications:
- Hypersensitivity to Naproxen or other NSAIDs.
- Avoid in patients with asthma, urticaria, or allergic reactions to aspirin or other NSAIDs.
- Perioperative pain following coronary artery bypass graft (CABG) surgery.
✔️ Pregnancy & Lactation:
- US FDA Pregnancy Category: C. Naproxen should generally be avoided during pregnancy and lactation unless the benefits outweigh the risks to the fetus.
✔️ Storage Conditions:
- Store below 30°C, protected from light and moisture.
- Keep out of reach of children.
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